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METRINO Academy Session #4 – One Spot, Many Eyes
Standardising Correlative Imaging for Nanomedicine
How can we reliably track nanoparticles inside biological tissues? Join the METRINO Academy session 4 on Thursday 26 March 2026 at 3 pm CET, and find out how correlative multimodal imaging workflows can improve the reliability of nanoparticle biodistribution studies by combining complementary analytical techniques within a structured, metrology driven pipeline (interactive Q&A included).
Full description of this webinar
Understanding where nanoparticles go in biological systems is critical for assessing their efficacy and safety in nanomedicine. However, nanoparticle biodistribution studies often rely on isolated imaging methods, leading to fragmented datasets and limited comparability between laboratories.
The METRINO Academy session #4 introduces a systematic pipeline for correlative imaging, designed to integrate multiple analytical techniques applied to the same region of interest within tissue samples. Using NaYF4 nanoparticles embedded in 3D tissue models and phantom tissue calibrators, the presentation will demonstrate how complementary methods including two photon excitation fluorescence microscopy (TPEF), SEM-EDX, ToF-SIMS and LA-ICP-MS can be combined within a structured analytical workflow.
By linking non destructive and high sensitivity techniques in a defined sequence, the approach establishes correlations between primary and indirect nanoparticle detection methods. The session will also highlight how these protocols feed into the METRINO interlaboratory comparison organised within the EURAMET framework, supporting the development of harmonised measurement approaches for nanomedicine research.
Speaker
Leonardo Mortati Researcher at Istituto Nazionale di Ricerca Metrologica (INRiM)
Session focus
Reliable nanoparticle localisation requires combining multiple imaging techniques within a coherent analytical strategy. In this session, we will cover:
- How correlative imaging workflows combine complementary techniques to study nanoparticle biodistribution in tissues
- The rationale behind sequencing non destructive and high sensitivity analytical methods within a measurement pipeline
- How analysing the same region of interest across multiple platforms enables cross validation of nanoparticle detection methods
- How the METRINO interlaboratory comparison contributes to building reproducible and comparable imaging protocols
Why attend
- Gain insight into how multi modal imaging can strengthen nanoparticle biodistribution studies
- Understand the strengths and limitations of different analytical techniques used in nanomedicine imaging
- Learn how structured measurement pipelines improve data reliability and comparability across laboratories
- Engage directly with experts through an interactive live Q&A session
Who is this for?
Open to both experts and non experts working in nanomedicine, imaging technologies, nanoparticle characterisation, metrology, analytical chemistry, quality control, regulatory science, or method development, whether from academia, industry, metrology institutes, or standards bodies.
Format
1:15 hour (hands on talk + live Q&A). Cameras welcome. Microphones muted by default.
Register here to attend the Academy Session #4
About METRINO
METRINO is a European project funded by the European Partnership on Metrology (Grant #22HLT04), co financed by the EU Horizon Europe programme and the Participating States. The project aims to strengthen nanomedicine metrology and support quality, safety and innovation. More information: metrino.eu
Join our growing METRINO community on LinkedIn and connect with researchers, industry and regulators working on nanomedicine metrology.
About the METRINO Academy
A short webinar series designed to translate METRINO outcomes into practical, user oriented guidance for the broader community, with a focus on real life decisions such as quality control, reproducibility and standardisation readiness.
If you missed the first sessions of the METRINO Academy, here are the links for the replay articles:
